Seputar Tumor Rahim22 Nov 2017
Estrogen: Long term exposure to hormonal birth control or hormone replacement therapy (post menopause) have a higher risk of reproductive system cancers, including cancer of the uterus. Rarer forms of uterine cancer that are also aggressive and tend to utilize the lymphatic system to metastasize include: Uterine sarcoma (develops in the connective tissue or muscle cells of the uterus), Adenosquamous carcinoma (which forms on the outside of the uterus), and Carcinomasarcoma (also begins in the endometrium). In women, they are most mostly found ‘incidentally’, during surgical tissue removal for other reasons, such as fibroids, uterine adenomyosis, uterine endometrial cancer, endometriosis, ovarian tumor, ovarian abscess, and tubal ligation procedures.
Uterine fibroids are tumors that are not cancerous that grow on or in the muscles of the uterus (womb). In Stage II, the cancer has spread within the uterus to cervical tissue (but not beyond), or to the stroma and glands where the cervix and uterus meet. However, sometimes Pap tests show signs of abnormal cells in the lining of the uterus (endometrium), which can be used to identify the potential presence of endometrial cancer.
Most appointments to diagnose endometrial cancer begin with a pelvic exam to check for abnormal areas or lumps around your vagina, cervix, uterus, fallopian tubes, ovaries, and rectum. Although benign uterine fibroids are common, with a lifetime risk of more than 70% for the average woman, uterine sarcoma is a rare condition. A small number of uterine cancers (about 2 percent) are sarcomas, which can originate in the endometrium or in the muscular and connective tissues of the uterus.
Cancer of the lining of the uterus, the endometrium, is the most common gynecologic cancer and ranks as one of the most treatable when identified in its earliest stages. Depending on the stage of your cancer, you may have a total hysterectomy, which involves removal of the whole uterus, cervix ovaries and fallopian tubes or a radical hysterectomy, which involves removal of tissue surrounding the uterus, in addition to removing the uterus and cervix. Stage III: Cancer cells have spread outside the uterus, such as the lymph nodes, fallopian tubes, ovaries or vagina.
In these cases, doctors will often opt for a procedure called dilation and curettage (D&C), in which the lining of the uterus is scraped and the cells examined more closely. Gonadotropin Releasing Hormone (GnRH) agonists- These medications (Lupron, Zoladex, Synarel, etc.) suppress the release of natural estrogen and progesterone production, which then causes shrinkage of fibroids and decrease in bleeding symptoms. As a growth factor, prolactin helps promote cell growth in normal tissue, but also plays a role in tumorigenesis, meaning the abnormal growth of benign tumors like fibroids and endometriotic lesions, as well as cancerous growths of reproductive and non-reproductive tract origin.
Concerns are increasing among doctors about the safety of a procedure performed on tens of thousands of women a year in the United States who undergo surgery to remove fibroid tumors from the uterus, or to remove the entire uterus.