Beast canker13 Nov 2017
The Canadian Task Force on Preventive Health Care, in 2011, released national recommendations on breast cancer screening for women aged 40 - 74 who are at average risk of developing breast cancer.
24, 2017 Women diagnosed with breast cancer may benefit from having the molecular subtype of different cells within their tumors identified, argue researchers. These types of breast cancers tend to spread more quickly and do not respond to hormone therapy or drugs that target HER2. The Canadian Cancer Society provides information about breast health: being breast aware; knowing about breast cancer risk factors and ways to help reduce the risk of breast cancer; and being informed about breast cancer screening.
Extended AI did not improve disease-free survival for all HR-positive breast cancers; however, certain high-risk patients may benefit from therapy beyond 5 years. The latest breast cancer treatments, including new alternatives to traditional chemotherapy that more precisely target cancer cells while sparing normal ones. Rarely, cancer can start in the breast’s connective tissue, a type known as sarcoma , or in the skin of the nipple, which is called Paget’s disease.
In many countries with advanced medical care, the five-year survival rate of early stage breast cancers is 80-90 per cent, falling to 24 per cent for breast cancers diagnosed at a more advanced stage. Lead researcher Dr Hongchao Pan, from University of Oxford, said: “It is remarkable that breast cancer can remain dormant for so long and then spread many years later, with this risk remaining the same year after year and still strongly related to the size of the original cancer and whether it had spread to the (lymph) nodes.” Women with small, low-grade cancers and no spread to the lymph nodes had a much lower 10% risk of cancer spread over that time.
Harris LN, Ismaila N, McShane LM, Andre F, Collyar DE, Gonzalez-Angulo AM, et al. Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline. Tang G, Cuzick J, Costantino JP, Dowsett M, Forbes JF, Crager M, et al. Risk of recurrence and chemotherapy benefit for patients with node-negative, estrogen receptor-positive breast cancer: recurrence score alone and integrated with pathologic and clinical factors. The Netherlands Cohort Study, which included 62,573 women aged 55-69 years with more than 20 years of follow-up, found that close adherence to a Mediterranean diet is associated with lower risk for breast cancer—in particular, for types of breast cancer that carry a poorer prognosis in postmenopausal women.
Infiltrating ductal carcinoma is the most commonly diagnosed breast tumor and has a tendency to metastasize via lymphatics; this lesion accounts for 75% of breast cancers. This view of breast cancer-not as a set of stochastic molecular events, but as a limited set of separable diseases of distinct molecular and cellular origins-has altered thinking about breast cancer etiology, type-specific risk factors, and prevention and has had a substantial impact on treatment strategies and breast cancer research. For many patients with low-risk early-stage breast cancer, surgery with local radiation is curative.
Surgery and radiation therapy, along with adjuvant hormone or chemotherapy when indicated, are now considered primary treatment for breast cancer. Mammograms are the staple of breast cancer surveillance, yet ionizing radiation—the kind in many high-tech screening tests—is a risk factor for the disease, because ionizing radiation can cause DNA mutations in cells. “Genetics is a very complicated topic, and genetic counselors can not only provide you with the most accurate, up-to-date information regarding your risk but also help you decide whether or not genetic testing is right for you,” says Sue Friedman, founder and director of FORCE (Facing Our Risk of Cancer Empowered), a national support network for people at high risk of breast and ovarian cancers.
Stage 0 breast cancer also has not spread to lymph nodes or other parts of the body. Stage 1 is an invasive cancer, meaning it is invading healthy breast tissue, but it has not spread outside the breast. It’s the most common type of non-invasive breast cancer, meaning the cells are abnormal but haven’t spread to the surrounding tissue.
Your treatment will depend on where your cancer started, whether it has invaded other breast tissue or spread to other parts of your body, and whether hormones like estrogen or progesterone fuel its growth, among other factors.
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